Stress failure plays an major role in development of High Altitude Pulmonary Edema in rats
نویسندگان
چکیده
Jun She , Jun Shen, Arnaud Goolaerts, Yuanlin Song, Ce Shen, Qunying Hong and Chunxue Bai Department of Pulmonary Medicine, Shanghai Sixth Hospital of Shanghai Jiaotong University; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Navy Medical Institute, Shanghai, China; Deaprtment of Anesthesia, San Francisco General Hospital, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA; # The institutions are not one after another. Corresponding Author: Chunxue Bai MD, PhD Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China Tel: +86-21-64041990-3077, E-mail: [email protected] . Published on September 9, 2009 as doi: 10.1183/09031936.00001709 ERJ Express
منابع مشابه
Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats.
Hypoxia and exertion are considered as the two main factors in the development of high-altitude pulmonary oedema (HAPE), however its pathophysiology remains unclear. Therefore, we established a model in which 32 Sprague-Dawley rats were randomly assigned to normoxic rest, hypoxic rest, normoxic exercise and hypoxic exercise. An altitude of 4,700 m was simulated using hypobaric hypoxia, while ex...
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متن کاملPathogenesis of high-altitude pulmonary oedema: direct evidence of stress failure of pulmonary capillaries.
The pathogenesis of high-altitude pulmonary oedema (HAPE) is disputed. Recent reports show a strong correlation between the occurrence of HAPE and pulmonary artery pressure, and it is known that the oedema is of the high-permeability type. We have, therefore, proposed that HAPE is caused by ultrastructural damage to pulmonary capillaries as a result of stress failure of their walls. However, no...
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H igh-altitude pulmonary oedema (HAPE) is a potentially fatal altitude illness affecting individuals within 2–4 days of rapid ascent to altitudes above 3,000 m. Although a minority of high-altitude travellers develop HAPE [1], there is some suggestion that many develop subclinical fluid accumulation without overt alveolar flooding [2]. The inciting mechanism of the injury to the lung in HAPE st...
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Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness. The present study was designed to investigate the ability of Rhodiola crenulata extract (RCE), an herbal medicine traditionally used as an antiacute mountain sickness remedy, to attenuate hypoxia-induce...
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